Elemental and molecular imaging by LA-ICP-MS
نویسندگان
چکیده
منابع مشابه
LA-iMageS: a software for elemental distribution bioimaging using LA–ICP–MS data
The spatial distribution of chemical elements in different types of samples is an important field in several research areas such as biology, paleontology or biomedicine, among others. Elemental distribution imaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is an effective technique for qualitative and quantitative imaging due to its high spatial resolution and s...
متن کاملElemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS.
cis-Diamminedichloroplatinum(II) (Cisplatin) is one of the most important and frequently used cytostatic drugs for the treatment of various solid tumors. Herein, a laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) method incorporating a fast and simple sample preparation protocol was developed for the elemental mapping of Cisplatin in the model organism Caenorhabditis eleg...
متن کاملCritical assessment of the elemental composition of Corning archeological reference glasses by LA-ICP-MS
Corning archeological reference glasses A, B, C, and D have been made to simulate different historic technologies of glass production and are used as standards in historic glass investigations. In this work, nanoseconds (193, 266 nm) and femtosecond (800 nm) laser ablation were used to study the elemental composition of Corning glasses using laser ablation inductively coupled plasma mass spectr...
متن کاملOrigin of phase contrast: insight from susceptibility, R2* and element imaging by LA-ICP-MS
Introduction: Recent progress in susceptibility reconstruction from single or multiple phase images [1,2,3] has led to a better characterisation of this novel contrast in the brain. A surprisingly large anisotropy of the reconstructed susceptibility of white matter has been observed and is being discussed [4,5,6]. However, neither the source of anisotropy nor that of susceptibility contrast are...
متن کاملThe influence of laser pulse duration and energy on ICP-MS signal intensity, elemental fractionation, and particle size distribution in NIR fs-LA-ICP-MS.
Laser parameters, typically wavelength, pulse width, irradiance, repetition rate, and pulse energy, are critical parameters which influence the laser ablation process and thereby influence the LA-ICP-MS signal. In recent times, femtosecond laser ablation has gained popularity owing to the reduction in fractionation related issues and improved analytical performance which can provide matrix-inde...
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ژورنال
عنوان ژورنال: Analytical and Bioanalytical Chemistry
سال: 2018
ISSN: 1618-2642,1618-2650
DOI: 10.1007/s00216-018-1523-7